CLINICAL RESEARCH POSTER PRESENTATION ABSTRACTS
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Salons 10-12.
THURSDAY, 5:30-6:15 PM
Berman S, Eichelsdorf P, Yim D, Elmer G, Wenner C.
A four species delayed release probiotic supplement enhances
phagocytosis by monocytes and neutrophils in a healthy, nonelderly adult
population.
Bastyr University sberman@bastyr.edu
In this pilot study we investigated whether
ingestion of a delayed release four species probiotic supplement over
an eight-week period would alter one or more immune parameters in a
healthy, nonelderly adult population. We chose three immune parameters
to examine in a population of ten adults between the ages of 24 and
54 (five men and five women); natural killer cell activity, phagocytic
activity in neutrophils and monocytes and salivary secretory IgA.
A repeated measures design was used in which
immune parameters were measured at baseline and three on-treatment time
points. Two baseline measures (day -7 and day 0) were assessed for natural
killer cell activity and secretory IgA levels, and one baseline measure
(day 0) was assessed for the phagocytosis endpoints. On-treatment measures
were taken at 3, 5 and 8 weeks.
Natural killer activity and phagocytic activity
were analyzed immediately after each collection on site. Salivary secretory
IgA samples were frozen upon collection at Ð80 degrees centigrade and
then sent together to Salimetrics Laboratory in State College, Pennsylvania
for enzyme immunoassay (EIA). There was a statistically significant
increase in the percent of phagocytosing monocytes (p=0.003) and neutrophils
(PMNs) (p= 0.020) over the eight-week treatment period, compared to
baseline.
There was no evidence of enhanced efficiency
of phagocytosis, NK cell activity or salivary secretory IgA over the
eight-week period.
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