POSTER PRESENTATION ABSTRACTS
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Salons 10-12.
THURSDAY, 5:30-6:15 PM
Yue KKM, Cho WCS, Leung AWN, Cheng CHK.
Ginsenoside Re of Panax ginseng has significant antioxidant
and antihyperlipidemic efficacy in streptozotocin-diabetic rats.
Hong Kong Baptist University kkmyue@hkbu.edu.hk
PURPOSE: To study whether ginsenoside Re, a
major component of Panax ginseng, could prevent the onset of oxidative
stress in eyes, aorta and kidneys of diabetic rats.
METHODS: 4 weeks after STZ induction, the diabetic
rats were treated with different doses (20 mg/kg, n=8; 10 mg/kg, n=8;
5 mg/kg, n=8) of ginsenoside Re or 20 mg/kg PVP-10 (solvent control,
n = 8) by oral intubation for 4 weeks. The blood glucose and lipid levels,
together with glutathione (GSH) and malondialdehyde (MDA) levels in
the eyes, aorta and kidneys were then measured. GSH being the primary
endogenous antioxidant and MDA is a marker of oxidative stress.
RESULTS: Diabetic rats treated with ginsenoside
Re showed a significant reduction in blood glucose, total cholesterol
and triglyceride levels. In addition, treatment by ginsenoside Re restored
the levels of both GSH and MDA in the eye and kidney to those found
in the control rats. No such changes were observed in the GSH and MDA
levels in the aorta of diabetic rats treated with ginsenoside Re.
CONCLUSIONS: These results demonstrated that
ginsenoside Re could lower blood glucose and cholesterol levels, and
exerts protective effects against the occurrence of oxidative stress
in the eye and kidney of diabetic rats. Our data provide evidence that
ginsenoside Re could be used as an effective antidiabetic agent particularly
in the prevention of diabetic microvasculopathy.
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