POSTER PRESENTATION ABSTRACTS
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FRIDAY, 5:45-6:30 PM
Yang SY, Chiang HM, Chao PDL.
Ginger profoundly decreased oral bioavailability of cyclosporin
in rats.
School of Pharmacy, China Medical University pdlee@mail.cmu.edu.tw
PURPOSE: Ginger (roots of Zingiber officinale
ROSCOE) is a popular spice and herbal medicine worldwide. Cyclosporin
is clinically used as an important immunosupressant with narrow therapeutic
index. This study attempted to investigate the effect of ginger on the
pharmacokinetics of cyclosporin in rats.
METHODS: Rats were orally administered cyclosporin
alone and coadministered with ginger juice (5 mL/kg) concomitantly as
well as 2 h before cyclosporin, respectively, in crossover designs.
In addition, rats were intravenously administered cyclosporin with and
without an oral dose of ginger juice (5 mL/kg). The blood samples were
withdrawn via cardiopuncture at predetermined time points and cyclosporin
concentrations were determined by a specific monoclonal fluorescence
polarization immunoassay. The pharmacokinetic parameters of cyclosporin
were calculated using noncompartment model of WINNONLIN.
RESULTS: The results indicated that concomitant
intake of ginger significantly decreased Cmax and AUC0-t of oral cyclosporin
by 70.9% and 63.1%, respectively. The intake of ginger 2 h before cyclosporin
significantly decreased Cmax and AUC0-t by 51.4% and 40.3%, respectively.
In contrast, the pharmacokinetics of intravenous cyclosporin was not
altered by oral coadministration of ginger juice.
CONCLUSIONS: In conclusion, ginger significantly
decreased the oral bioavailability of cyclosporin. The interaction should
occur at the absorption phase. Patients treated with cyclosporin should
be discouraged from using ginger products to ensure the efficacy of
cyclosporin.
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