POSTER PRESENTATION ABSTRACTS
Please note: All posters will be displayed in
Salons 10-12.
FRIDAY, 10:15-11:00 AM
Seidman MD, Patel N, Leong F, Tang W, Jiang H, Bai U,
Media J, Nakeff A, Levine RA, Quirk WS.
Resveratrol decreases noise-induced cyclooxygenase-2
_expression in cochlea and protects from noise induced hearing loss.
Henry Ford Health System Center for Integrative
Medicine Mseidma1@hfhs.org
Our previous studies have demonstrated the efficacy
of resveratrol to reduce temporary threshold shifts and decrease cochlear
hair cell damage following noise exposure. The current study was designed
to identify the potential protective mechanism of resveratrol from noise
induced hearing loss (NIHL) by measuring cyclooxygenase-2 (Cox-2) protein
_expression and free radicals formation. The results showed progressive
upregulation of Cox-2, beginning at 8 hours and reaching a maximum at
24 hours. Cox-2 _expression in the noise with vehicle-treated group
was significantly increased as compared to the control group. Cox-2
_expression in the noise with varying doses of resveratrol (3 test doses)
was significantly reduced as compared to the noise with vehicle-treated
group. In the control group, little or no Cox-2 _expression was detected.
Free radicals formation with resveratrol-treated subjects was significantly
inhibited as compared to vehicle-treated group. These data indicate
that Cox-2 levels can be induced dramatically following noise exposure
and this increase can be inhibited by resveratrol. These findings suggest
that inhibition of the inflammatory mediator, Cox-2 may be a putative
mechanism for protection from NIHL by resveratrol.
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