POSTER PRESENTATION ABSTRACTS
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Salons 10-12.
THURSDAY, 5:30-6:15 PM
Roffey B, Atwal A, Johns T, Kubow S
A water extract from Momordica charantia fruit
and seeds increases glucose uptake in 3T3-L1 adipose cells in the presence
of a sub-optimal concentration of insulin.
McGill University benjamin.roffey@mail.mcgill.ca
To examine the effects of Momordica charantia
(MC) on glucose uptake in fat cells, 3T3-L1 adipocytes were treated
with three concentrations of water and ethanol extracts of MC fruit
and seeds. Treatments consisted of the extracts alone and the extracts
in combination with two concentrations of insulin. The treatment combination
of 0.2 mg/ml MC water extract and 0.5 nM insulin was associated with
an increased glucose uptake into the cells (61%). The MC ethanol extract
was not associated with an increase in glucose uptake; however, a dose-dependent
decrease in basal glucose uptake and insulin-mediated glucose uptake
was observed with the MC ethanol extract in combination with 50 nM insulin.
The present results indicate that preferentially water-soluble component(s)
in MC fruit and/or seed enhance the glucose uptake action of sub-optimal
concentrations of insulin in 3T3-L1 adipocytes.
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