POSTER PRESENTATION ABSTRACTS
Please note: All posters will be displayed in
Salons 10-12.
THURSDAY, 10:15-11:00 AM
Lin B, Saul I, Busto R, Fernandez G, Guillerm L.
Combination of Chinese herbal medicine alleviated acute
intracerebral hemorrhage (ICH) injury in rats.
C V D Research Center, University of Miami, FL
lin@stroke.med.miami.edu
PURPOSE: ICH has been much less studied. Strategies,
we consider, include removing hematoma and decreasing damage in perihematoma
regions.
METHODS: We employed 2 hemorrhage models, consisting
of injecting either 100 µl of blood into striatum or 50 µl
into cortex in 12 rats (n=3 in each group including treated and control
ones). Rats were orally administrated an herb for 2 days to arrest bleeding
and resolve or dispel extravasated blood and our 9-herb decoction for
6 days to attenuate the peri-hematoma edema and remove the blood and
its degradations, initiated at 2 hrs after blood injection. Beam-walking
test was performed after ICH. Brains were collected on the 7th day survival
for histological exam. Since the first herb contains ginsenoside Rb1,
it is able to stabilize the membrane structure of mitochondria of neurons.
In cortex protocol, treated rats received a one-time intravenous injection
of a compound from another natural medicine at 1 hr after hemorrhage
to enhance the mitochondrial protection.
RESULTS: Histological exam revealed that hematoma
disappeared in treated rats while it persisted in nontreated ones in
the cortex protocol. The peri-hematoma structural destruction was less
severe in treated rats than control group, and beam-walking test showed
that treated rats traverse at least 2 days earlier in the striatal protocol.
The pilot studies imply these 11 natural medicines encouraged CNS healing
and functional recovery after brain hemorrhage.
CONCLUSION: The multiple targeting and combination
therapy made of by the 11 natural medicines displayed the neuroprotection
in ICH damage in rats.
Back