POSTER PRESENTATION ABSTRACTS
Please note: All posters will be displayed in
Salons 10-12.
THURSDAY, 10:15-11:00 AM
Fang SH, Hou YC, Hsiu SL, Chao PDL.
Pharmacokinetic and pharmacodynamic interactions of peels
of Citrus grandis and cyclosporin in mice.
Department of Microbiology, School of Medicine,
China Medical University shfang@mail.cmu.edu.tw
A previous study indicated that the coadministration
of decoction of Citri Grandis Pericarpium (CGP), the peels of Citrus
grandis (Rutaceae), significantly increased the blood level of cyclosporin
(CsA) and resulted in acute intoxication of pigs. In this study, we
aimed to measure the effects of CGP on the distribution of CsA in both
lymphoid and non-lymphoid tissues as well as on the immune cell function
in mice. Our results showed that coadministration of 3 g/kg CGP with
CsA (Neoral®, 10 mg/kg) significantly decreased the concentrations
of CsA in blood, liver, kidney and spleen by 35 %, 45 %, 53 % and 58
%, respectively, after two-wk treatment. The decrease of CsA level was
found well correlated with the dose of CGP. However, coadministration
of CGP restored the phagocytosis activity decreased by CsA in blood.
Moreover, the nitric oxide production of activated macrophages and helper
T cell type 1 (Th1) cytokines production suppressed by CsA were also
reversed by the coadministration of CGP. In conclusion, coadministration
of CGP significantly decreased the systemic exposure of CsA in mice.
However, the pharmacodynamic interaction compensated the pharmacokinetic
effect.
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